Artificial intelligence and artificial immune systems: transforming tuberculosis diagnosis
DOI:
https://doi.org/10.18011/bioeng.2025.v19.1272Keywords:
Medical Innovation, Healthcare Efficiency, Negative Selection Algorithm, Disease DetectionAbstract
Tuberculosis (TB) is one of the world’s deadliest infectious diseases, making rapid and accurate diagnosis essential for its control. However, challenges such as a lack of infrastructure and qualified professionals hinder detection, especially in low- and middle-income countries. In this scenario, Artificial Intelligence (AI) and Artificial Immune Systems (AIS) emerge as innovative tools to enhance TB diagnosis. AI has been applied to the analysis of chest X-rays and molecular tests, increasing accuracy and reducing diagnosis time. Deep learning algorithms can identify subtle patterns in medical exams, achieving accuracy levels comparable to those of specialists. Meanwhile, AIS, inspired by the human immune system, stands out for their adaptability and continuous learning, making them highly effective in recognizing complex cases. Artificial intelligence has enormous potential to improve the diagnosis and treatment of tuberculosis, making medical care more efficient and accessible. This study presents solutions that can enhance diagnostic accuracy and efficiency, enabling faster and more targeted interventions. By combining these technologies with traditional methods, efforts to combat tuberculosis can be optimized, reducing its spread and global mortality.
Downloads
References
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2002). Molecular biology of the cell (4th ed.). Garland Science.
Almeida, E. F., Chavarette, F. R., Merizio, I. F., & Gonçalves, A. C. (2024). Artificial immune system for fault detection and localization in a composite material plate with temperature variation. Journal of the Brazilian Society of Mechanical Sciences and Engineering, 46, 717.
Bradley, D.W., (2002), Tyrrell, A.M., Immunotronics-novel finite-state-machine architectures with built-in self-test using self-nonself differentiation. IEEE Transactions on Evolutionary Computation, 6, 227-238.
Bauer, D., Timmis, J., & De Castro, L. N. (2005). An immune system inspired algorithm for the optimization of a dynamic multi-criteria problem. International Journal of Computational Intelligence and Applications, 5(3), 331–343.
Bill & Melinda Gates Foundation. (2023). Leveraging AI for tuberculosis control in low-resource settings. BMGF. Retrieved from www.gatesfoundation.org
Brasil. (2023). Sistema de Informação de Agravos de Notificação (SINAN). Departamento de Informática do SUS. Retrieved from www.datasus.gov.br
De Castro, L. N., & Timmis, J. (2002). Artificial immune systems: A new computational intelligence approach. Springer.
Forrest, S., Perelson, A.S., Allen, L., & Cheukuri, R., (1994), Self-Nonself Discrimination in a Computer, IEEE Computer Society Symposium on Research in Security and Privacy, DOI: https://doi.org/10.1109/RISP.1994.296580.
Fuzinatto, S. B., Vaccaro, V. S., Martins, M. J., Focchesatto, S. P., da Silveira, A. J., de Conto, R. P., & Zancanaro, V. (2024). Tuberculose: quadro clínico, diagnóstico e tratamento: uma revisão narrativa da literatura. Cuadernos de Educación y Desarrollo, 16(6), e4572-e4572.
Janeway, C. A., Travers, P., Walport, M., & Shlomchik, M. J. (2001). Immunobiology: The immune system in health and disease (5th ed.). Garland Science.
Jones, R., et al. (2022). Predictive modeling for tuberculosis risk assessment using machine learning. BMC Public Health, 22(1), 1–10.
Lee, H., et al. (2023). Artificial immune systems for tuberculosis diagnosis: A comparative study. Journal of Computational Biology, 30(4), 512–525.
Medzhitov, R., & Janeway, C. A. (2000). Innate immunity. New England Journal of Medicine, 343(5), 338–344.
Murphy, K., & Weaver, C. (2017). Janeway’s immunobiology (9th ed.). Garland Science.
Silva, R., et al. (2022). Artificial immune systems in healthcare: Applications and challenges. Artificial Intelligence in Medicine, 112, 102030.
Smith, J., et al. (2023). Deep learning for tuberculosis detection in chest radiographs: A comparative study. Journal of Medical Artificial Intelligence, 5(2), 45–56.
Soares, G., Chavarette, F. R., Gonçalves, A. C., Faria, H. A. M., Outa, R., & Mishra, V. N. (2025). Optimizing the transition: Replacing conventional lubricants with biological alternatives through artificial intelligence. Journal of Applied and Computational Mechanics, 11, 294–302. DOI: 10.22055/JACM.2024.47162.4665
World Health Organization (WHO). (2023). Artificial intelligence in tuberculosis diagnosis: Progress and challenges. WHO. Retrieved from www.who.int
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 The Authors

This work is licensed under a Creative Commons Attribution 4.0 International License.
By publishing in this journal, authors agree to the following terms:
a) Authors retain copyright and grant the journal the right of first publication. The work is simultaneously licensed under the Creative Commons Attribution License, which permits sharing and adaptation of the work with appropriate credit to the authors and the journal.
b) Authors may enter into separate, additional agreements for non-exclusive distribution of the published version of the work (e.g., posting to an institutional repository or inclusion in a book), provided that proper credit is given to the original publication in this journal.



